5. Davis, K., Philpott, S., Kumar, D. and Mendall, M., 2006. Randomised double‐blind placebo‐controlled trial of aloe vera for irritable bowel syndrome. International journal of clinical practice, 60(9), pp.1080-1086. Link
6. Hong, S.W., Chun, J., Park, S., Lee, H.J., Im, J.P. and Kim, J.S., 2018. Aloe vera is effective and safe in short-term treatment of irritable bowel syndrome: a systematic review and meta-analysis. Journal of neurogastroenterology and motility, 24(4), p.528. Link
7. Khan, S. and Chang, L., 2010. Diagnosis and management of IBS. Nature reviews Gastroenterology & hepatology, 7(10), p.565. Link
8. Hawrelak, J.A. and Myers, S.P., 2010. Effects of two natural medicine formulations on irritable bowel syndrome symptoms: a pilot study. The Journal of Alternative and Complementary Medicine, 16(10), pp.1065-1071. Link
9. Tarasiuk, A., Mosińska, P. and Fichna, J., 2018. Triphala: current applications and new perspectives on the treatment of functional gastrointestinal disorders. Chinese medicine, 13(1), p.39. Link
10. Madisch, A., Holtmann, G., Plein, K. and Hotz, J., 2004. Treatment of irritable bowel syndrome with herbal preparations: results of a double‐blind, randomized, placebo‐controlled, multi‐centre trial. Alimentary pharmacology & therapeutics, 19(3), pp.271-279. Link
11. Quart, B.D. and Rosenbaum, D.P., Napo Pharmaceuaticals Inc, 2011. Method for treatment of constipation-predominant irritable bowel syndrome. U.S. Patent 8,067,041. Link
12. Ottillinger, B., Storr, M., Malfertheiner, P. and Allescher, H.D., 2013. STW 5 (Iberogast®)—a safe and effective standard in the treatment of functional gastrointestinal disorders. Wiener Medizinische Wochenschrift, 163(3-4), pp.65-72. Link
13. Simmen, U., Kelber, O., Okpanyi, S.N., Jaeggi, R., Bueter, B. and Weiser, D., 2006. Binding of STW 5 (Iberogast®) and its components to intestinal 5-HT, muscarinic M3, and opioid receptors. Phytomedicine, 13, pp.51-55. Link
14. De Roest, R.H., Dobbs, B.R., Chapman, B.A., Batman, B., O'brien, L.A., Leeper, J.A., Hebblethwaite, C.R. and Gearry, R.B., 2013. The low FODMAP diet improves gastrointestinal symptoms in patients with irritable bowel syndrome: a prospective study. International journal of clinical practice, 67(9), pp.895-903. Link
15. Nanayakkara, W.S., Skidmore, P.M., O’Brien, L., Wilkinson, T.J. and Gearry, R.B., 2016. Efficacy of the low FODMAP diet for treating irritable bowel syndrome: the evidence to date. Clinical and experimental gastroenterology, 9, p.131. Link
16. Whigham, L., Joyce, T., Harper, G., Irving, P.M., Staudacher, H.M., Whelan, K. and Lomer, M.C.E., 2015. Clinical effectiveness and economic costs of group versus one‐to‐one education for short‐chain fermentable carbohydrate restriction (low FODMAP diet) in the management of irritable bowel syndrome. Journal of human nutrition and dietetics, 28(6), pp.687-696. Link
17. Shulman, R.J., Hollister, E.B., Cain, K., Czyzewski, D.I., Self, M.M., Weidler, E.M., Devaraj, S., Luna, R.A., Versalovic, J. and Heitkemper, M., 2017. Psyllium fiber reduces abdominal pain in children with irritable bowel syndrome in a randomized, double-blind trial. Clinical Gastroenterology and Hepatology, 15(5), pp.712-719. Link
18. Böhn, L., Störsrud, S., Liljebo, T., Collin, L., Lindfors, P., Törnblom, H. and Simrén, M., 2015. Diet low in FODMAPs reduces symptoms of irritable bowel syndrome as well as traditional dietary advice: a randomized controlled trial. Gastroenterology, 149(6), pp.1399-1407. Link
19. McFarland, L.V. and Dublin, S., 2008. Meta-analysis of probiotics for the treatment of irritable bowel syndrome. World journal of gastroenterology: WJG, 14(17), p.2650. Link
20. Moayyedi, P., Ford, A.C., Talley, N.J., Cremonini, F., Foxx-Orenstein, A.E., Brandt, L.J. and Quigley, E.M., 2010. The efficacy of probiotics in the treatment of irritable bowel syndrome: a systematic review. Gut, 59(3), pp.325-332. Link
21. Kerckhoffs, A.P., Samsom, M., van der Rest, M.E., de Vogel, J., Knol, J., Ben-Amor, K. and Akkermans, L.M., 2009. Lower Bifidobacteria counts in both duodenal mucosa-associated and fecal microbiota in irritable bowel syndrome patients. World journal of gastroenterology: WJG, 15(23), p.2887. Link
22. Bittner, A.C., Croffut, R.M. and Stranahan, M.C., 2005. Prescript-assist™ probiotic-prebiotic treatment for irritable bowel syndrome: A methodologically oriented, 2-week, randomized, placebo-controlled, double-blind clinical study. Clinical therapeutics, 27(6), pp.755-761. Link
23. Blanchard, E.B., Lackner, J.M., Jaccard, J., Rowell, D., Carosella, A.M., Powell, C., Sanders, K., Krasner, S. and Kuhn, E., 2008. The role of stress in symptom exacerbation among IBS patients. Journal of Psychosomatic research, 64(2), pp.119-128. Link
24. Blanchard, E.B., Greene, B., Scharff, L. and Schwarz-McMorris, S.P., 1993. Relaxation training as a treatment for irritable bowel syndrome. Biofeedback and Self-regulation, 18(3), pp.125-132. Link
25. Boxwell, A. and Eichler, D., 2006. The efficacy of guided imagery/visualization & journaling in patients with irritable bowel syndrome. Subtle Energies & Energy Medicine Journal Archives, 16(2). Link
26. Bremner, H., 2013. Nurse-led hypnotherapy: an innovative approach to Irritable Bowel Syndrome. Complementary therapies in clinical practice, 19(3), pp.147-152. Link
27. Ströhle, A., 2009. Physical activity, exercise, depression and anxiety disorders. Journal of neural transmission, 116(6), p.777. Link
28. Daley, A.J., Grimmett, C., Roberts, L., Wilson, S., Fatek, M., Roalfe, A. and Singh, S., 2008. The effects of exercise upon symptoms and quality of life in patients diagnosed with irritable bowel syndrome: a randomised controlled trial. International journal of sports medicine, 29(09), pp.778-782. Link
29. Daley, A.J., Grimmett, C., Roberts, L., Wilson, S., Fatek, M., Roalfe, A. and Singh, S., 2008. The effects of exercise upon symptoms and quality of life in patients diagnosed with irritable bowel syndrome: a randomised controlled trial. International journal of sports medicine, 29(09), pp.778-782. Link
30. Kuttner, L., Chambers, C.T., Hardial, J., Israel, D.M., Jacobson, K. and Evans, K., 2006. A randomized trial of yoga for adolescents with irritable bowel syndrome. Pain Research and Management, 11(4), pp.217-224. Link
31. Taneja, I., Deepak, K.K., Poojary, G., Acharya, I.N., Pandey, R.M. and Sharma, M.P., 2004. Yogic versus conventional treatment in diarrhea-predominant irritable bowel syndrome: a randomized control study. Applied psychophysiology and biofeedback, 29(1), pp.19-33. Link
32. Kavuri, V., Raghuram, N., Malamud, A. and Selvan, S.R., 2015. Irritable bowel syndrome: yoga as remedial therapy. Evidence-Based Complementary and Alternative Medicine, 2015. Link
33. Dinan, T.G. and Cryan, J.F., 2017. Gut–brain axis in 2016: Brain–gut–microbiota axis—mood, metabolism and behaviour. Nature Reviews Gastroenterology & Hepatology, 14(2), p.69. Link
34. Toner, B.B., 2005. Cognitive-behavioral treatment of irritable bowel syndrome. CNS spectrums, 10(11), pp.883-890. Link
35. Lackner, J.M., Jaccard, J., Krasner, S.S., Katz, L.A., Gudleski, G.D. and Holroyd, K., 2008. Self-administered cognitive behavior therapy for moderate to severe irritable bowel syndrome: clinical efficacy, tolerability, feasibility. Clinical Gastroenterology and Hepatology, 6(8), pp.899-906. Link
36. Lindfors, P., Unge, P., Arvidsson, P., Nyhlin, H., Björnsson, E., Abrahamsson, H. and Simrén, M., 2012. Effects of gut-directed hypnotherapy on IBS in different clinical settings—results from two randomized, controlled trials. American Journal of Gastroenterology, 107(2), pp.276-285. Link
37. Peters, S.L., Yao, C.K., Philpott, H., Yelland, G.W., Muir, J.G. and Gibson, P.R., 2016. Randomised clinical trial: the efficacy of gut‐directed hypnotherapy is similar to that of the low FODMAP diet for the treatment of irritable bowel syndrome. Alimentary pharmacology & therapeutics, 44(5), pp.447-459. Link
38. Mayo Clinic. 2020. Over-The-Counter Laxatives For Constipation: Use With Caution. [online] Available at: <https://www.mayoclinic.org/diseases-conditions/constipation/in-depth/laxatives/art-20045906> [Accessed 27 April 2020]. Link